Role of C14orf166 in viral infection and RNA metabolism and its relationship with cancer (Review)

Chromosome 14 open reading frame 166 (C14orf166) encodes a 28‑kDa nuclear and cytoplasmic protein that is involved in viral infection, RNA metabolism, centrosome structure. It binds to the polymerase acidic subunit of influenza A virus, which associated with several transcription factors, II, activate initiation promote virus infection. also interacts mature hepatitis C core regulate infection process. In physiological conditions, C14orf166 associates proteins, DDX1, HSPC117 FAM98B, regulates metabolism fate. addition, overexpressed variety cancer types. Upregulation may contribute toward malignancy through its impact on glycogen synthase kinase 3β‑mediated signaling, downregulation retinoblastoma protein, or upregulation IL‑6. Therefore, could be used as biomarker for diagnosis prognosis various This review summarized existent literature about C14orf166, focusing functions pathological situations.